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ythc-2 RNA helicase [ Caenorhabditis elegans ]

Gene ID: 172615, updated on 9-Dec-2024

Summary

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Official Symbol
ythc-2
Official Full Name
RNA helicase
Primary source
WormBase:WBGene00009922
Locus tag
CELE_F52B5.3
See related
AllianceGenome:WB:WBGene00009922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and helicase activity. Orthologous to human YTHDC2 (YTH N6-methyladenosine RNA binding protein C2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ythc-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (8318347..8323987, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Transcription factor cep-1 Neighboring gene Large ribosomal subunit protein uL23B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
  2. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
  3. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA helicase
NP_492260.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8318347..8323987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059859.5 → NP_492260.1  RNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20644
    Conserved Domains (7) summary
    smart00393
    Location:21 → 100
    R3H; Putative single-stranded nucleic acids-binding domain
    smart00487
    Location:189 → 369
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:869 → 948
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:198 → 338
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:647 → 764
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:984 → 1116
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    pfam08597
    Location:393 → 470
    eIF3_subunit; Translation initiation factor eIF3 subunit
Nucleotide Protein
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