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tnsl-1 Tonsoku-like protein [ Caenorhabditis elegans ]

Gene ID: 172642, updated on 2-Nov-2024

Summary

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Official Symbol
tnsl-1
Official Full Name
Tonsoku-like protein
Primary source
WormBase:WBGene00010498
Locus tag
CELE_K02B12.5
See related
AllianceGenome:WB:WBGene00010498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Orthologous to human TONSL (tonsoku like, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tnsl-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
22
Sequence:
Chromosome: I; NC_003279.8 (8517453..8526621, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Myb_DNA-bind_3 domain-containing protein Neighboring gene Axin-like protein 1 Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Arf-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Zip homologous protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tonsoku-like protein
NP_001361839.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8517453..8526621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001374927.3 → NP_001361839.1  Tonsoku-like protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21117
    Conserved Domains (3) summary
    sd00033
    Location:970 → 989
    LRR_RI; leucine-rich repeat [structural motif]
    sd00045
    Location:515 → 546
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:519 → 629
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
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