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K02B12.7 Arf-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172643, updated on 2-Nov-2024

Summary

Official Symbol
K02B12.7
Official Full Name
Arf-GAP domain-containing protein
Primary source
WormBase:WBGene00010500
Locus tag
CELE_K02B12.7
See related
AllianceGenome:WB:WBGene00010500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in Golgi membrane. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See K02B12.7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (8526758..8529271, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tonsoku-like protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Zip homologous protein 3 Neighboring gene Guanine nucleotide-binding protein alpha-15 subunit

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Arf-GAP domain-containing protein
NP_492310.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8526758..8529271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059909.6NP_492310.1  Arf-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492310.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90904
    Conserved Domains (1) summary
    cd08830
    Location:6121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1