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gpa-15 Guanine nucleotide-binding protein alpha-15 subunit [ Caenorhabditis elegans ]

Gene ID: 172645, updated on 2-Nov-2024

Summary

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Official Symbol
gpa-15
Official Full Name
Guanine nucleotide-binding protein alpha-15 subunit
Primary source
WormBase:WBGene00001677
Locus tag
CELE_M04C7.1
See related
AllianceGenome:WB:WBGene00001677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is expressed in chemosensory neurons and hermaphrodite somatic gonadal cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpa-15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (8531684..8534527, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Arf-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Zip homologous protein 3 Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans. Burghoorn J, et al. Proc Natl Acad Sci U S A, 2007 Apr 24. PMID 17420466, Free PMC Article
  2. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Jansen G, et al. Nat Genet, 1997 Sep. PMID 9288111
  3. Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Kim K, et al. Science, 2009 Nov 13. PMID 19797623, Free PMC Article
  4. unc-42 regulates the expression of ASH terminal fate markers. Wood J, et al. MicroPubl Biol, 2019 May 15. PMID 32550468, Free PMC Article
  5. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents. Hilliard MA, et al. EMBO J, 2005 Jan 12. PMID 15577941, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Guanine nucleotide-binding protein alpha-15 subunit
NP_492312.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8531684..8534527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059911.3 → NP_492312.1  Guanine nucleotide-binding protein alpha-15 subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492312.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91907, Q9BIG1
    Conserved Domains (2) summary
    cd00066
    Location:35 → 350
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:14 → 354
    G_alpha; G protein alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91907.2

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