cdk-8 Cyclin-dependent kinase 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdk-8
Official Full Name: Cyclin-dependent kinase 8
Primary source: WormBase:WBGene00000409
Locus tag: CELE_F39H11.3
See related: AllianceGenome:WB:WBGene00000409
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and protein phosphorylation. Predicted to be active in nucleus. Is expressed in anchor cell and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87 and dilated cardiomyopathy. Orthologous to human CDK19 (cyclin dependent kinase 19) and CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cdk-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (8702466..8705825)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK-8 Mediator kinase module acts together with a proneural protein, HLH-2, and in parallel to the proneural protein HLH-3 to promote I4 neurogenesis.
Title: The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage.
we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling-lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM).our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants
Title: Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans.
The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation.
Title: The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39H11.3 (e-PCR)
- UniSTS:310217

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Cyclin-dependent kinase 8

NP_492357.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8702466..8705825

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059956.7 → NP_492357.2 Cyclin-dependent kinase 8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492357.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P90866

Conserved Domains (2) summary

smart00220
Location:26 → 348

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07842
Location:26 → 348

STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases