imp-1 IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: imp-1
Official Full Name: IntraMembrane Protease (IMPAS) family
Primary source: WormBase:WBGene00007979
Locus tag: CELE_C36B1.12
See related: AllianceGenome:WB:WBGene00007979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Predicted to be involved in membrane protein proteolysis. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A); SPPL2B (signal peptide peptidase like 2B); and SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See imp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (8752229..8755680)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C36B1.12 (e-PCR)
- UniSTS:309265

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic endopeptidase activity, intramembrane cleaving	IEA Inferred from Electronic Annotation more info
enables aspartic endopeptidase activity, intramembrane cleaving	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane protein proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi-associated vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi-associated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasmic side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in lumenal side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: IntraMembrane Protease (IMPAS) family

NP_001021023.1

Product from WormBase gene class imp;
Confirmed by transcript evidence

NP_001021024.1

Product from WormBase gene class imp;
Confirmed by transcript evidence

NP_001021025.1

Product from WormBase gene class imp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8752229..8755680

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025854.6 → NP_001021025.1 IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021025.1

Status: REVIEWED

UniProtKB/TrEMBL

Q564X0

Conserved Domains (1) summary

pfam04258
Location:275 → 601

Peptidase_A22B; Signal peptide peptidase
NM_001025852.5 → NP_001021023.1 IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021023.1

Status: REVIEWED

UniProtKB/TrEMBL

Q93346

Conserved Domains (1) summary

pfam04258
Location:275 → 601

Peptidase_A22B; Signal peptide peptidase
NM_001025853.6 → NP_001021024.1 IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021024.1

Status: REVIEWED

UniProtKB/TrEMBL

Q564X1

Conserved Domains (1) summary

pfam04258
Location:275 → 601

Peptidase_A22B; Signal peptide peptidase