trt-1 Telomerase reverse transcriptase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: trt-1
Official Full Name: Telomerase reverse transcriptase
Primary source: WormBase:WBGene00006618
Locus tag: CELE_DY3.4
See related: AllianceGenome:WB:WBGene00006618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity; metal ion binding activity; and telomerase activity. Involved in telomere maintenance via telomerase. Predicted to be located in chromosome, telomeric region and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trt-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (8768521..8771248)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
Title: Null allele mutants of trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration.
Telomerase may be required to prevent or repair sporadic telomere truncations that are unrelated to the typical 'end-replication' problems.
Title: High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
Title: trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.

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General gene information

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Markers

DY3.3 (e-PCR)
- UniSTS:318043

DY3.4 (e-PCR)
- UniSTS:306402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables telomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Telomerase reverse transcriptase

NP_001359628.1

Partially confirmed by transcript evidence

NP_492373.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8768521..8771248

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059972.7 → NP_492373.1 Telomerase reverse transcriptase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492373.1

Status: REVIEWED

UniProtKB/TrEMBL

O45321

Conserved Domains (1) summary

cd01648
Location:433 → 536

TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
NM_001373211.4 → NP_001359628.1 Telomerase reverse transcriptase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95QP3

Conserved Domains (1) summary

cd01648
Location:379 → 482

TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...