tgs-1 Trimethylguanosine synthase [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: tgs-1
Official Full Name: Trimethylguanosine synthase
Primary source: WormBase:WBGene00011631
Locus tag: CELE_T08G11.4
See related: AllianceGenome:WB:WBGene00011631
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be active in nucleus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See tgs-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (8902741..8905447, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T08G11.4 (e-PCR)
- UniSTS:310745

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA cap trimethylguanosine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine cap hypermethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine cap hypermethylation	IEA Inferred from Electronic Annotation more info
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Trimethylguanosine synthase

NP_001122517.1

Confirmed by transcript evidence

NP_492400.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8902741..8905447 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059999.5 → NP_492400.1 Trimethylguanosine synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492400.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94013

Conserved Domains (1) summary

cl17173
Location:396 → 553

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001129045.4 → NP_001122517.1 Trimethylguanosine synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122517.1

Status: REVIEWED

UniProtKB/TrEMBL

A8WHU4

Conserved Domains (1) summary

cl17173
Location:325 → 482

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...