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syx-7 t-SNARE coiled-coil homology domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172718, updated on 2-Nov-2024

Summary

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Official Symbol
syx-7
Official Full Name
t-SNARE coiled-coil homology domain-containing protein
Primary source
WormBase:WBGene00009478
Locus tag
CELE_F36F2.4
See related
AllianceGenome:WB:WBGene00009478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. Orthologous to human STX12 (syntaxin 12) and STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See syx-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (9001911..9003963, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tubulin alpha chain Neighboring gene Fatty acid synthase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase II subunit A C-terminal domain phosphatase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis. Jantsch-Plunger V, et al. Curr Biol, 1999 Jul 15. PMID 10421575
  2. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
  3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
t-SNARE coiled-coil homology domain-containing protein
NP_492422.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9001911..9003963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060021.9 → NP_492422.2  t-SNARE coiled-coil homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492422.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62236
    Conserved Domains (2) summary
    smart00503
    Location:3 → 111
    SynN; Syntaxin N-terminal domain
    cd15847
    Location:156 → 215
    SNARE_syntaxin7_like; SNARE motif of syntaxin 7, 12 and related sequences
Nucleotide Protein
Heading Accession and Version

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