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hxk-1 Phosphotransferase [ Caenorhabditis elegans ]

Gene ID: 172751, updated on 9-Dec-2024

Summary

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Official Symbol
hxk-1
Official Full Name
Phosphotransferase
Primary source
WormBase:WBGene00008780
Locus tag
CELE_F14B4.2
See related
AllianceGenome:WB:WBGene00008780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hxk-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (9271479..9278689, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog Neighboring gene DUF305 domain-containing protein;F-box domain-containing protein Neighboring gene Phosphatase and actin regulator 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans. Gu QL, et al. J Zhejiang Univ Sci B, 2020 Jan.. PMID 31898444, Free PMC Article
  2. MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans. Takasaki T, et al. Development, 2007 Feb. PMID 17215300, Free PMC Article
  3. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Bender LB, et al. Development, 2006 Oct. PMID 16968818, Free PMC Article
  4. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  5. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphotransferase
NP_001021106.1
  • Confirmed by transcript evidence
NP_001370182.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9271479..9278689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383604.2 → NP_001370182.1  Phosphotransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6BET1
    Conserved Domains (1) summary
    COG5026
    Location:16 → 482
    COG5026; Hexokinase [Carbohydrate transport and metabolism]

  2. NM_001025935.5 → NP_001021106.1  Phosphotransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021106.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19440
    Conserved Domains (3) summary
    COG5026
    Location:37 → 487
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam00349
    Location:39 → 233
    Hexokinase_1; Hexokinase
    pfam03727
    Location:239 → 480
    Hexokinase_2; Hexokinase
Nucleotide Protein
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