uggt-2 UDP-glucose:Glycoprotein Glucosyltransferase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: uggt-2
Official Full Name: UDP-glucose:Glycoprotein Glucosyltransferase
Primary source: WormBase:WBGene00009178
Locus tag: CELE_F26H9.8
See related: AllianceGenome:WB:WBGene00009178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Involved in IRE1-mediated unfolded protein response; regulation of embryonic development; and regulation of nematode larval development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1) and UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in UDP-glucosylation	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

NP_492484.2

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The following sections contain reference sequences that belong to a specific genome build. Explain