lin-41 Protein lin-41 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-41
Official Full Name: Protein lin-41
Primary source: WormBase:WBGene00003026
Locus tag: CELE_C12C8.3
See related: AllianceGenome:WB:WBGene00003026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA binding activity and translation repressor activity. Involved in several processes, including negative regulation of gene expression; nematode male tail tip morphogenesis; and positive regulation of brood size. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and ribonucleoprotein granule. Is expressed in several structures, including germ cell; hypodermal cell; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-41 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 16

Sequence:: Chromosome: I; NC_003279.8 (9334807..9342496, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
Title: Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
Parallel genetics of regulatory sequences using scalable genome editing in vivo.
Title: Parallel genetics of regulatory sequences using scalable genome editing in vivo.
daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71.
Title: daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71.
Findings show that the timing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in the nervous system of the Caenorhabditis elegans male is controlled by the temporally regulated miRNA let-7 and its target protein lin-41 (lin-41).
Title: Timing mechanism of sexually dimorphic nervous system differentiation.
These results identify let-7-LIN41 as a versatile regulatory module and reveal how several levels of post-transcriptional regulation promote transition into adulthood through controlling transcriptional programs.
Title: let-7 coordinates the transition to adulthood through a single primary and four secondary targets.
Mechanisms Inactivate the LIN-41 RNA-Binding Protein To Ensure a Robust Oocyte-to-Embryo Transition in Caenorhabditis elegans
Title: Multiple Mechanisms Inactivate the LIN-41 RNA-Binding Protein To Ensure a Robust Oocyte-to-Embryo Transition in Caenorhabditis elegans.
A positively charged pocket, specific to the NHL domain of LIN-41 recognizes a stem-loop RNA element, whose shape determines the binding specificity.
Title: Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
LIN-41 represses translation of spn-4 and meg-1during oocyte meiotic maturation and the oocyte-to-embryo transition.
Title: LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans.
Study reports that the stem cell fate regulator LIN41 silences mRNAs through two distinct and separable mechanisms: translational repression or degradation. Choice of mechanism is specified by the location of the LIN41- binding site on the target mRNA.
Title: LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms.
Lin-41 regulates the gene expression required for timely centrosome elimination around the diplotene stage in female germ cells.
Title: LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C12C8.3 (e-PCR)
- UniSTS:309047

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein lin-41

NP_001020998.1

Confirmed by transcript evidence

NP_001020999.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9334807..9342496 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025828.7 → NP_001020999.1 Protein lin-41 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020999.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U489

Conserved Domains (5) summary

smart00502
Location:515 → 641

BBC; B-Box C-terminal domain

smart00336
Location:474 → 512

BBOX; B-Box-type zinc finger

COG3391
Location:843 → 1140

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd14954
Location:819 → 1143

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00630
Location:689 → 808

Filamin; Filamin/ABP280 repeat
NM_001025827.6 → NP_001020998.1 Protein lin-41 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020998.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U489, Q9U490

Conserved Domains (5) summary

smart00502
Location:519 → 645

BBC; B-Box C-terminal domain

smart00336
Location:478 → 516

BBOX; B-Box-type zinc finger

COG3391
Location:847 → 1144

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd14954
Location:823 → 1147

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00630
Location:693 → 812

Filamin; Filamin/ABP280 repeat