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fce-1 CAAX prenyl protease 1 homolog [ Caenorhabditis elegans ]

Gene ID: 172820, updated on 9-Dec-2024

Summary

Official Symbol
fce-1
Official Full Name
CAAX prenyl protease 1 homolog
Primary source
WormBase:WBGene00001405
Locus tag
CELE_C04F12.10
See related
AllianceGenome:WB:WBGene00001405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables metalloendopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See fce-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (9711066..9712719, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNase H type-1 domain-containing protein Neighboring gene BSD domain-containing protein Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CAAX-box protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CAAX prenyl protease 1 homolog
NP_492582.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9711066..9712719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060181.7NP_492582.1  CAAX prenyl protease 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XVE5
    Conserved Domains (3) summary
    COG0501
    Location:75440
    HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
    pfam01435
    Location:204436
    Peptidase_M48; Peptidase family M48
    pfam16491
    Location:28201
    Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices