ocrl-1 Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ocrl-1
Official Full Name: Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00007620
Locus tag: CELE_C16C2.3
See related: AllianceGenome:WB:WBGene00007620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and signal transduction. Predicted to be located in early endosome membrane and phagocytic vesicle membrane. Predicted to be active in cytoplasm; membrane; and neuron projection. Human ortholog(s) of this gene implicated in Dent disease 2 and oculocerebrorenal syndrome. Orthologous to several human genes including INPP5B (inositol polyphosphate-5-phosphatase B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ocrl-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (9715322..9728006, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16C2.3 (e-PCR)
- UniSTS:306736

C16C2.1 (e-PCR)
- UniSTS:319045

C16C2.2 (e-PCR)
- UniSTS:321228

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rho-GAP domain-containing protein

NP_001122421.1

Partially confirmed by transcript evidence

NP_001361846.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9715322..9728006 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001375161.2 → NP_001361846.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O17590

Conserved Domains (2) summary

cd09074
Location:39 → 356

INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases

cd04380
Location:496 → 705

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
NM_001128949.5 → NP_001122421.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122421.1

Status: REVIEWED

UniProtKB/TrEMBL

A5Z2U3

Conserved Domains (1) summary

cd04380
Location:55 → 264

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...