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sys-1 Beta-catenin homolog sys-1 [ Caenorhabditis elegans ]

Gene ID: 172859, updated on 9-Dec-2024

Summary

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Official Symbol
sys-1
Official Full Name
Beta-catenin homolog sys-1
Primary source
WormBase:WBGene00006379
Locus tag
CELE_T23D8.9
See related
AllianceGenome:WB:WBGene00006379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; scaffold protein binding activity; and transcription coactivator activity. Involved in several processes, including cell fate commitment involved in formation of primary germ layer; gonad development; and regulation of gene expression. Located in several cellular components, including cell cortex; kinetochore; and pericentriolar material. Is expressed in several structures, including ABplpapaap; ABprpapaap; P7.pa; posterior distal tip cell; and tail hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sys-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (9980063..9984794, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein LTV1 homolog Neighboring gene Eukaryotic translation initiation factor 3 subunit C Neighboring gene ncRNA Neighboring gene Histone H4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans SYS-1 protein is a bona fide beta-catenin. Liu J, et al. Dev Cell, 2008 May. PMID 18477457, Free PMC Article
  2. Centrosomal enrichment and proteasomal degradation of SYS-1/β-catenin requires the microtubule motor dynein. Thompson JW, et al. Mol Biol Cell, 2022 May 1. PMID 35196020, Free PMC Article
  3. Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans. Zacharias AL, et al. PLoS Genet, 2015 Oct. PMID 26488501, Free PMC Article
  4. Functional analyses of vertebrate TCF proteins in C. elegans embryos. Robertson SM, et al. Dev Biol, 2011 Jul 1. PMID 21539828, Free PMC Article
  5. The sys-1 gene and sexual dimorphism during gonadogenesis in Caenorhabditis elegans. Miskowski J, et al. Dev Biol, 2001 Feb 1. PMID 11161562

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results indicate that SYS-1 and POP-1 levels are influenced by the parent cell's SYS-1/POP-1 levels and this may provide an additional mechanism by which POP-1 regulates distinct targets in different developmental contexts.
    Title: Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans.
  2. Data show that centrosomal targeting of SYS-1 promotes its degradation during asymmetric cell division.
    Title: Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division.
  3. SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1
    Title: Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.
  4. Animals with reduced function of the beta-catenins SYS-1 and WRM-1 have as few as 3 seam cells. The 'Wnt/beta-catenin asymmetry' pathway is required for the proper stem cell-like asymmetric division of seam cells.
    Title: Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development.
  5. Either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis.
    Title: The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.
  6. SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
    Title: The C. elegans SYS-1 protein is a bona fide beta-catenin.
  7. There are two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates.
    Title: Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1.
  8. binds the POP-1/TCF beta-catenin binding domain, and coactivates POP-1-dependent transcription
    Title: A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling.
  9. SYS-1 causes all SGP daughters to adopt the proximal fate.
    Title: Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.
  10. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans.
    Title: Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic digestive tract development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polarity specification of proximal/distal axis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in polarity specification of proximal/distal axis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Beta-catenin homolog sys-1
NP_001300438.1
  • Confirmed by transcript evidence
NP_001379282.1
  • Confirmed by transcript evidence
NP_492639.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9980063..9984794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060238.6 → NP_492639.1  Beta-catenin homolog sys-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3ARA0, Q95ZN3, Q9XVI2

  2. NM_001392922.1 → NP_001379282.1  Beta-catenin homolog sys-1 [Caenorhabditis elegans]

    Status: REVIEWED

  3. NM_001313509.3 → NP_001300438.1  Beta-catenin homolog sys-1 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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