U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pash-1 DRBM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172950, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
pash-1
Official Full Name
DRBM domain-containing protein
Primary source
WormBase:WBGene00011908
Locus tag
CELE_T22A3.5
See related
AllianceGenome:WB:WBGene00011908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in several processes, including primary miRNA processing; regulation of epidermal cell differentiation; and regulation of vulval development. Predicted to be part of microprocessor complex. Is expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pash-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (10598673..10606621)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-18 Neighboring gene ncRNA Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene Kringle domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene Laminin subunit alpha lam-3 Neighboring gene Repressor of RNA polymerase III transcription MAF1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A whole-mount in situ hybridization method for microRNA detection in Caenorhabditis elegans. Andachi Y, et al. RNA, 2016 Jul. PMID 27154969, Free PMC Article
  2. Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans. Lehrbach NJ, et al. RNA, 2012 Dec. PMID 23097426, Free PMC Article
  3. Dissection of the Caenorhabditis elegans Microprocessor. Nguyen TL, et al. Nucleic Acids Res, 2023 Feb 28. PMID 36598924, Free PMC Article
  4. Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans. Rios C, et al. Dev Biol, 2017 Jun 1. PMID 28461238, Free PMC Article
  5. Tissue-specific overexpression of systemic RNA interference components limits lifespan in C. elegans. Camara H, et al. Gene, 2024 Feb 15. PMID 37984536

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional loss of pash-1 activity resulted in a reduced rate of ovulation and in basal and ovulatory sheath contractions.
    Title: Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans.
  2. role for pash-1 in miRNA maturation and miRNA-mediated gene regulation.
    Title: Processing of primary microRNAs by the Microprocessor complex.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables primary miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary miRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microprocessor complex IEA
Inferred from Electronic Annotation
more info
  
part_of microprocessor complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DRBM domain-containing protein
NP_001293461.1
  • Confirmed by transcript evidence
NP_001293462.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10598673..10606621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306532.2 → NP_001293461.1  DRBM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRH5
    Conserved Domains (2) summary
    smart00456
    Location:175 → 205
    WW; Domain with 2 conserved Trp (W) residues
    pfam00035
    Location:449 → 472
    dsrm; Double-stranded RNA binding motif

  2. NM_001306533.3 → NP_001293462.1  DRBM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293462.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEM4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools