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mafr-1 Repressor of RNA polymerase III transcription MAF1 [ Caenorhabditis elegans ]

Gene ID: 172953, updated on 4-Jan-2025

Summary

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Official Symbol
mafr-1
Official Full Name
Repressor of RNA polymerase III transcription MAF1
Primary source
WormBase:WBGene00016622
Locus tag
CELE_C43H8.2
See related
AllianceGenome:WB:WBGene00016622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase III core binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase III. Located in cytoplasm and nucleus. Is expressed in hypodermis and intestine. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mafr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (10623173..10624361)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DRBM domain-containing protein Neighboring gene tRNA-Gly Neighboring gene Laminin subunit alpha lam-3 Neighboring gene Protein archease-like Neighboring gene ATP-dependent RNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation. Hammerquist AM, et al. Mol Biol Cell, 2021 May 15. PMID 33788576, Free PMC Article
  2. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. Pradhan A, et al. J Mol Biol, 2017 Jan 20. PMID 27986570, Free PMC Article
  3. Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion. Cai Y, et al. Oncotarget, 2016 Mar 8. PMID 26934328, Free PMC Article
  4. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Khanna A, et al. Cell Rep, 2014 Dec 24. PMID 25497095, Free PMC Article
  5. Maf1 phenotypes and cell physiology. Willis IM. Biochim Biophys Acta Gene Regul Mech, 2018 Apr. PMID 29248739, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation.
    Title: Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation.
  2. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans.
    Title: Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans.
  3. MAFR-1 impacts lipid transport by modulating intestinal expression of the vitellogenin family of proteins, resulting in cell-nonautonomous defects in the developing reproductive system.
    Title: Physiological roles for mafr-1 in reproduction and lipid homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase III core binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Repressor of RNA polymerase III transcription MAF1
NP_492777.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10623173..10624361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060376.5 → NP_492777.1  Repressor of RNA polymerase III transcription MAF1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZN2
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 217
    Maf1; Maf1 regulator
Nucleotide Protein
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