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fkb-7 peptidylprolyl isomerase [ Caenorhabditis elegans ]

Gene ID: 172963, updated on 4-Jan-2025

Summary

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Official Symbol
fkb-7
Official Full Name
peptidylprolyl isomerase
Primary source
WormBase:WBGene00001432
Locus tag
CELE_B0511.1
See related
AllianceGenome:WB:WBGene00001432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14) and FKBP7 (FKBP prolyl isomerase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fkb-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (10667808..10671357)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DEK_C domain-containing protein Neighboring gene pseudo Neighboring gene Pecanex-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
  2. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
  3. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidylprolyl isomerase
NP_492792.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10667808..10671357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060391.4 → NP_492792.1  peptidylprolyl isomerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61826
    Conserved Domains (2) summary
    pfam00254
    Location:86 → 179
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    cl08302
    Location:190 → 256
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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