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spcs-1 Signal peptidase complex subunit 1 [ Caenorhabditis elegans ]

Gene ID: 172967, updated on 4-Jan-2025

Summary

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Official Symbol
spcs-1
Official Full Name
Signal peptidase complex subunit 1
Primary source
WormBase:WBGene00016395
Locus tag
CELE_C34B2.10
See related
AllianceGenome:WB:WBGene00016395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in IRE1-mediated unfolded protein response. Located in endoplasmic reticulum. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spcs-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (10682472..10683048, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene Lon protease homolog, mitochondrial Neighboring gene Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Rolls MM, et al. Mol Biol Cell, 2002 May. PMID 12006669, Free PMC Article
  2. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
  3. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article
  4. Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans. Ferrier A, et al. PLoS One, 2011. PMID 22073173, Free PMC Article
  5. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Poteryaev D, et al. Mol Biol Cell, 2005 May. PMID 15716356, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Signal peptidase complex subunit 1
NP_492797.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10682472..10683048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060396.6 → NP_492797.1  Signal peptidase complex subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492797.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44953
    Conserved Domains (1) summary
    pfam06645
    Location:19 → 90
    SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44953.1

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