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gly-15 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 [ Caenorhabditis elegans ]

Gene ID: 173114, updated on 9-Dec-2024

Summary

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Official Symbol
gly-15
Official Full Name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Primary source
WormBase:WBGene00001640
Locus tag
CELE_C54C8.11
See related
AllianceGenome:WB:WBGene00001640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycosyltransferase activity. Predicted to be located in Golgi membrane. Is expressed in g2L and g2R. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to several human genes including GCNT1 (glucosaminyl (N-acetyl) transferase 1); GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type); and GCNT4 (glucosaminyl (N-acetyl) transferase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gly-15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (12462176..12465816)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C-type LECtin Neighboring gene pseudo Neighboring gene Neuropeptide-Like Protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues. Warren CE, et al. Glycobiology, 2001 Nov. PMID 11744632
  2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
NP_001263539.1
  • Confirmed by transcript evidence
NP_493164.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12462176..12465816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060763.4 → NP_493164.2  Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493164.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEZ8
    Conserved Domains (1) summary
    pfam02485
    Location:105 → 297
    Branch; Core-2/I-Branching enzyme

  2. NM_001276610.3 → NP_001263539.1  Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263539.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E6J1
    Conserved Domains (1) summary
    pfam02485
    Location:105 → 157
    Branch; Core-2/I-Branching enzyme
Nucleotide Protein
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Gene LinkOut

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