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pri-2 DNA primase large subunit [ Caenorhabditis elegans ]

Gene ID: 173122, updated on 14-Nov-2024

Summary

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Official Symbol
pri-2
Official Full Name
DNA primase large subunit
Primary source
WormBase:WBGene00004181
Locus tag
CELE_W02D9.1
See related
AllianceGenome:WB:WBGene00004181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; DNA binding activity; and metal ion binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pri-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (12528304..12532135, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Protein YIPF Neighboring gene HMG box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. Yoon DS, et al. FEBS J, 2018 Jul. PMID 29775245, Free PMC Article
  2. The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks. Xu J, et al. G3 (Bethesda), 2024 Apr 3. PMID 38267027, Free PMC Article
  3. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Encalada SE, et al. Dev Biol, 2000 Dec 15. PMID 11112326
  4. A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans. Nelson MD, et al. PLoS Genet, 2011 Mar. PMID 21408209, Free PMC Article
  5. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Colaiácovo MP, et al. Genetics, 2002 Sep. PMID 12242227, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings suggest that the subunits of the DNA polymerase alpha-primase complex exhibit both discrete and shared functions in GLP-1/Notch or PUF-mediated germ cell dynamics in C. elegans.
    Title: Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA primase large subunit
NP_001251922.1
  • Confirmed by transcript evidence
NP_001251923.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12528304..12532135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264993.2 → NP_001251922.1  DNA primase large subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02334
    Conserved Domains (1) summary
    cd07322
    Location:43 → 475
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

  2. NM_001264994.3 → NP_001251923.1  DNA primase large subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D7SFP4
    Conserved Domains (1) summary
    cd07322
    Location:3 → 294
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02334.2

Gene LinkOut

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