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fkb-2 peptidylprolyl isomerase [ Caenorhabditis elegans ]

Gene ID: 173160, updated on 9-Dec-2024

Summary

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Official Symbol
fkb-2
Official Full Name
peptidylprolyl isomerase
Primary source
WormBase:WBGene00001427
Locus tag
CELE_Y18D10A.19
See related
AllianceGenome:WB:WBGene00001427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1A (FKBP prolyl isomerase 1A); FKBP1B (FKBP prolyl isomerase 1B); and FKBP1C (FKBP prolyl isomerase family member 1C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fkb-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (12918722..12919280)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene peptidylprolyl isomerase Neighboring gene Profilin-1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans. Dridi H, et al. Elife, 2022 May 4. PMID 35506650, Free PMC Article
  2. An Optogenetic Arrhythmia Model-Insertion of Several Catecholaminergic Polymorphic Ventricular Tachycardia Mutations Into Caenorhabditis elegans UNC-68 Disturbs Calstabin-Mediated Stabilization of the Ryanodine Receptor Homolog. Engel MA, et al. Front Physiol, 2022. PMID 35399287, Free PMC Article
  3. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
  4. COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells. Osterli E, et al. Genetics, 2024 May 7. PMID 38427913,
  5. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidylprolyl isomerase
NP_001021722.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12918722..12919280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026551.7 → NP_001021722.1  peptidylprolyl isomerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021722.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27462, Q9U2Q8
    Conserved Domains (1) summary
    pfam00254
    Location:15 → 105
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
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