aex-6 small monomeric GTPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aex-6
Official Full Name: small monomeric GTPase
Primary source: WormBase:WBGene00000089
Locus tag: CELE_Y87G2A.4
See related: AllianceGenome:WB:WBGene00000089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in exocytosis; positive regulation of defecation; and positive regulation of protein catabolic process. Located in synaptic vesicle. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to several human genes including RAB27A (RAB27A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See aex-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (13543068..13545188, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
Title: rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
RAB-27/AEX-6 is involved in the tethering of DCVs and its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking
Title: RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y87G2A.j (e-PCR)
- UniSTS:324130

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle tethering involved in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small monomeric GTPase

NP_493376.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13543068..13545188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060975.6 → NP_493376.1 small monomeric GTPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493376.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBS5, I7FXD9

Conserved Domains (2) summary

cd04127
Location:4 → 182

Rab27A; Rab GTPase family 27a (Rab27a)

pfam00071
Location:9 → 180

Ras; Ras family