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ndua-2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [ Caenorhabditis elegans ]

Gene ID: 173279, updated on 9-Dec-2024

Summary

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Official Symbol
ndua-2
Official Full Name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Primary source
WormBase:WBGene00013406
Locus tag
CELE_Y63D3A.7
See related
AllianceGenome:WB:WBGene00013406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 13. Orthologous to human NDUFA2 (NADH:ubiquinone oxidoreductase subunit A2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ndua-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (14113636..14114085)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein tfg-1 Neighboring gene J domain-containing protein Neighboring gene TLC domain-containing protein fld-1 Neighboring gene histone acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. Falk MJ, et al. PLoS One, 2009 Aug 12. PMID 19672299, Free PMC Article
  2. The role of mitochondria in the life of the nematode, Caenorhabditis elegans. Tsang WY, et al. Biochim Biophys Acta, 2003 Jul 14. PMID 12853115
  3. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
NP_493465.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14113636..14114085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061064.8 → NP_493465.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493465.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWG2
    Conserved Domains (1) summary
    smart00916
    Location:22 → 91
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Nucleotide Protein
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