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npp-4 Nucleoporin p58/p45 [ Caenorhabditis elegans ]

Gene ID: 173329, updated on 4-Jan-2025

Summary

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Official Symbol
npp-4
Official Full Name
Nucleoporin p58/p45
Primary source
WormBase:WBGene00003790
Locus tag
CELE_Y54E5A.4
See related
AllianceGenome:WB:WBGene00003790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Involved in several processes, including determination of adult lifespan; establishment of mitotic spindle orientation; and nucleus organization. Predicted to be part of nuclear pore central transport channel. Is expressed in intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See npp-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (14701122..14706522, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Neighboring gene Recep_L_domain domain-containing protein Neighboring gene Polysaccharide biosynthesis domain-containing protein Neighboring gene DRBM domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;CTLH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, et al. Dev Cell, 2017 Oct 23. PMID 29065307, Free PMC Article
  2. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter A, et al. Dev Biol, 2006 Jan 15. PMID 16325795, Free PMC Article
  3. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article
  4. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. D'Angelo MA, et al. Cell, 2009 Jan 23. PMID 19167330, Free PMC Article
  5. A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Vastenhouw NL, et al. Curr Biol, 2003 Aug 5. PMID 12906791

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nucleoporin p58/p45
NP_493552.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14701122..14706522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061151.6 → NP_493552.1  Nucleoporin p58/p45 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493552.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWK3
    Conserved Domains (1) summary
    pfam13634
    Location:21 → 122
    Nucleoporin_FG; Nucleoporin FG repeat region
Nucleotide Protein
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