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rpt-4 putative 26S proteasome regulatory subunit 10B [ Caenorhabditis elegans ]

Gene ID: 173384, updated on 9-Dec-2024

Summary

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Official Symbol
rpt-4
Official Full Name
putative 26S proteasome regulatory subunit 10B
Primary source
WormBase:WBGene00004504
Locus tag
CELE_F23F1.8
See related
AllianceGenome:WB:WBGene00004504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of protein stability. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cytosolic proteasome complex and proteasome regulatory particle, base subcomplex. Is expressed in nervous system and pharynx. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpt-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (42207..46216, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Nuclear transcription factor Y subunit nfyc-1 Neighboring gene RNA polymerase I associated factor, A49-like protein Neighboring gene Nucleolus and neural progenitor protein-like N-terminal domain-containing protein Neighboring gene Serine palmitoyltransferase 1 Neighboring gene Trehalase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Vora S, et al. Curr Biol, 2015 Apr 20. PMID 25819561
  2. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. Peel N, et al. J Cell Sci, 2012 Aug 1. PMID 22623721, Free PMC Article
  3. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Martinez BA, et al. Cell Death Dis, 2015 Oct 15. PMID 26469957, Free PMC Article
  4. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article
  5. A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome. Davy A, et al. EMBO Rep, 2001 Sep. PMID 11559592, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
putative 26S proteasome regulatory subunit 10B
NP_001022113.1
  • Confirmed by transcript evidence
NP_001022114.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    42207..46216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026942.5 → NP_001022113.1  putative 26S proteasome regulatory subunit 10B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17071, Q5F4U7
    Conserved Domains (2) summary
    COG1222
    Location:21 → 404
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    pfam00004
    Location:188 → 320
    AAA; ATPase family associated with various cellular activities (AAA)

  2. NM_001026943.5 → NP_001022114.1  putative 26S proteasome regulatory subunit 10B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022114.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17071
    Conserved Domains (2) summary
    COG1222
    Location:13 → 396
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    pfam00004
    Location:180 → 312
    AAA; ATPase family associated with various cellular activities (AAA)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17071.2

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