nfyc-1 Nuclear transcription factor Y subunit nfyc-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nfyc-1
Official Full Name: Nuclear transcription factor Y subunit nfyc-1
Primary source: WormBase:WBGene00017742
Locus tag: CELE_F23F1.1
See related: AllianceGenome:WB:WBGene00017742
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription repressor activity. Involved in negative regulation of transcription by RNA polymerase II and tissue development. Located in cytoplasm and perikaryon. Is expressed in several structures, including gonad. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nfyc-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (43907..44917)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Title: The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23F1.1 (e-PCR)
- UniSTS:309912

F23F1.8 (e-PCR)
- UniSTS:309914

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear transcription factor Y subunit nfyc-1

NP_001300537.1

Confirmed by transcript evidence

NP_493645.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

43907..44917

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061244.8 → NP_493645.1 Nuclear transcription factor Y subunit nfyc-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493645.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AWV9, O17072

Conserved Domains (1) summary

COG5208
Location:65 → 206

HAP5; CCAAT-binding factor, subunit C [Transcription]
NM_001313608.3 → NP_001300537.1 Nuclear transcription factor Y subunit nfyc-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWV9

Conserved Domains (1) summary

COG5208
Location:30 → 171

HAP5; CCAAT-binding factor, subunit C [Transcription]