alh-6 Aldehyde dehydrogenase domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: alh-6
Official Full Name: Aldehyde dehydrogenase domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase
Primary source: WormBase:WBGene00000112
Locus tag: CELE_F56D12.1
See related: AllianceGenome:WB:WBGene00000112
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrial matrix. Is expressed in body wall musculature; head; hypodermis; and tail. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See alh-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (1306243..1309754, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species.
Title: Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species.
we identify and confirm the mutations in xrep-2, xrep-3, and xrep-4 The xrep-2 gene is alh-6, an ortholog of a human gene mutated in familial hyperprolinemia. The xrep-3 mutation is a gain-of-function allele of skn-1 The xrep-4 gene is F46F11.6, which encodes a F-box-containing protein. We demonstrate that xrep-4 alters the stability of WDR-23 (xrep-1), a key regulator of SKN-1 (xrep-3).
Title: A Genetic Analysis of the Caenorhabditis elegans Detoxification Response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56D12.1 (e-PCR)
- UniSTS:314496

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proline catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in proline metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aldehyde dehydrogenase domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase

NP_001022212.1

Partially confirmed by transcript evidence

NP_001040782.1

Confirmed by transcript evidence

NP_493946.1

Confirmed by transcript evidence

NP_871951.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

1306243..1309754 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061545.7 → NP_493946.1 L-glutamate gamma-semialdehyde dehydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493946.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC31

Conserved Domains (1) summary

cd07123
Location:34 → 552

ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
NM_182151.6 → NP_871951.1 L-glutamate gamma-semialdehyde dehydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871951.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86N72

Conserved Domains (1) summary

cl11961
Location:34 → 490

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
NM_001047317.6 → NP_001040782.1 L-glutamate gamma-semialdehyde dehydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040782.1

Status: REVIEWED

UniProtKB/TrEMBL

G4RZC3

Conserved Domains (1) summary

cl11961
Location:1 → 412

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
NM_001027041.9 → NP_001022212.1 Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022212.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6A593

Conserved Domains (1) summary

cl11961
Location:34 → 379

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily