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ZK1240.3 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173588, updated on 4-Jan-2025

Summary

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Official Symbol
ZK1240.3
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00022868
Locus tag
CELE_ZK1240.3
See related
AllianceGenome:WB:WBGene00022868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ZK1240.3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (2320334..2321951)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_001300609.1
  • Confirmed by transcript evidence
NP_001364681.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2320334..2321951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377717.1 → NP_001364681.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16680
    Conserved Domains (2) summary
    cl00034
    Location:91 → 132
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:5 → 51
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001313680.3 → NP_001300609.1  RING-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU33
    Conserved Domains (1) summary
    TIGR02987
    Location:28 → 123
    met_A_Alw26; type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family
Nucleotide Protein
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