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gbas-1 G-protein alpha subunit activating protein gbas-1 [ Caenorhabditis elegans ]

Gene ID: 173603, updated on 4-Jan-2025

Summary

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Official Symbol
gbas-1
Official Full Name
G-protein alpha subunit activating protein gbas-1
Primary source
WormBase:WBGene00019130
Locus tag
CELE_F59H5.1
See related
AllianceGenome:WB:WBGene00019130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables G-protein alpha-subunit binding activity and guanyl-nucleotide exchange factor activity. Involved in small GTPase-mediated signal transduction. Is expressed in several structures, including GLR; coelomocyte; distal tip cell; intestine; and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gbas-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (2504878..2514905)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation. DiGiacomo V, et al. Biochemistry, 2018 Jan 23. PMID 29035513, Free PMC Article
  2. Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Coleman BD, et al. Mol Biol Evol, 2016 Mar. PMID 26659249, Free PMC Article
  3. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein alpha subunit activating protein gbas-1
NP_494285.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2504878..2514905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061884.7 → NP_494285.2  G-protein alpha subunit activating protein gbas-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494285.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86RS8, Q9TZI4
    Conserved Domains (2) summary
    smart00583
    Location:375 → 482
    SPK; domain in SET and PHD domain containing proteins and protein kinases
    cl11619
    Location:229 → 318
    SPK; Domain of unknown function (DUF545)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TZI4.2

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