srpa-72 Signal recognition particle subunit SRP72 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: srpa-72
Official Full Name: Signal recognition particle subunit SRP72
Primary source: WormBase:WBGene00017245
Locus tag: CELE_F08D12.1
See related: AllianceGenome:WB:WBGene00017245
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See srpa-72 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (2787481..2793943)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08D12.1 (e-PCR)
- UniSTS:319216

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 7S RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
contributes_to ribosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Signal recognition particle subunit SRP72

NP_494366.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

2787481..2793943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061965.7 → NP_494366.2 Signal recognition particle subunit SRP72 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494366.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91240

Conserved Domains (3) summary

sd00006
Location:105 → 166

TPR; TPR repeat [structural motif]

pfam08492
Location:515 → 571

SRP72; SRP72 RNA-binding domain

pfam17004
Location:21 → 153

SRP_TPR_like; Putative TPR-like repeat