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ctsa-1.1 Serine carboxypeptidase ctsa-1.1 [ Caenorhabditis elegans ]

Gene ID: 173818, updated on 4-Jan-2025

Summary

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Official Symbol
ctsa-1.1
Official Full Name
Serine carboxypeptidase ctsa-1.1
Primary source
WormBase:WBGene00018271
Locus tag
CELE_F41C3.5
See related
AllianceGenome:WB:WBGene00018271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ctsa-1.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (4737648..4739802)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene Ovule protein;WD_REPEATS_REGION domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene putative Golgi transport protein 1 Neighboring gene fatty Acid CoA Synthetase family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
  2. The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. Reece-Hoyes JS, et al. Nucleic Acids Res, 2009 Jun. PMID 19372275, Free PMC Article
  3. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine carboxypeptidase ctsa-1.1
NP_494846.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4737648..4739802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062445.7 → NP_494846.1  Serine carboxypeptidase ctsa-1.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494846.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52717
    Conserved Domains (1) summary
    pfam00450
    Location:23 → 465
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52717.1

Gene LinkOut

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