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tbck-1 TBC domain-containing protein kinase-like protein [ Caenorhabditis elegans ]

Gene ID: 173832, updated on 4-Jan-2025

Summary

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Official Symbol
tbck-1
Official Full Name
TBC domain-containing protein kinase-like protein
Primary source
WormBase:WBGene00016352
Locus tag
CELE_C33F10.2
See related
AllianceGenome:WB:WBGene00016352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in infantile hypotonia with psychomotor retardation and characteristic facies-3. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tbck-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (4828559..4832472)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142 Neighboring gene F-box domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. Gruneberg U, et al. J Cell Biol, 2002 Sep 2. PMID 12213836, Free PMC Article
  2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TBC domain-containing protein kinase-like protein
NP_001364726.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4828559..4832472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377792.2 → NP_001364726.1  TBC domain-containing protein kinase-like protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18386
    Conserved Domains (2) summary
    smart00164
    Location:444 → 654
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl21453
    Location:42 → 238
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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