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sahd-1 Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [ Caenorhabditis elegans ]

Gene ID: 173937, updated on 9-Dec-2024

Summary

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Official Symbol
sahd-1
Official Full Name
Deoxynucleoside triphosphate triphosphohydrolase sahd-1
Primary source
WormBase:WBGene00022673
Locus tag
CELE_ZK177.8
See related
AllianceGenome:WB:WBGene00022673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables dGTPase activity; deoxynucleoside triphosphate hydrolase activity; and protein homodimerization activity. Involved in dGTP catabolic process. Predicted to be located in chromosome. Predicted to be active in nucleus. Is expressed in several structures, including excretory cell; hypodermis; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sahd-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (5509022..5514945, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein fzy-1 Neighboring gene putative cytochrome P450 CYP44 Neighboring gene Protein npp-24 Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog. Maehigashi T, et al. J Biol Chem, 2023 Sep. PMID 37567474, Free PMC Article
  2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables dGTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dGTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxynucleoside triphosphate hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dGTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dGTP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deoxyribonucleotide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Deoxynucleoside triphosphate triphosphohydrolase sahd-1
NP_001412556.1
  • Confirmed by transcript evidence
NP_001412557.1
  • Partially confirmed by transcript evidence
NP_001412558.1
  • Confirmed by transcript evidence
NP_495054.1
  • Confirmed by transcript evidence
NP_495055.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5509022..5514945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062653.4 → NP_495054.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495054.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09374, Q95PX5
    Conserved Domains (1) summary
    cd00077
    Location:90 → 284
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  2. NM_062654.6 → NP_495055.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495055.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09374
    Conserved Domains (1) summary
    cd00077
    Location:56 → 250
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  3. NM_001425627.1 → NP_001412556.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001425628.1 → NP_001412557.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

    Status: REVIEWED

  5. NM_001425629.1 → NP_001412558.1  Deoxynucleoside triphosphate triphosphohydrolase sahd-1 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09374.2

Gene LinkOut

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