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F59E12.6 ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

Gene ID: 173951, updated on 4-Jan-2025

Summary

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Official Symbol
F59E12.6
Official Full Name
ubiquitinyl hydrolase 1
Primary source
WormBase:WBGene00019122
Locus tag
CELE_F59E12.6
See related
AllianceGenome:WB:WBGene00019122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Predicted to be involved in negative regulation of ERAD pathway. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F59E12.6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (5626815..5630951, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 3 subunit L Neighboring gene Nuclear protein localization protein 4 homolog 2 Neighboring gene Protein kinase domain-containing protein Neighboring gene pseudo Neighboring gene Nuclear protein localization protein 4 homolog 1 Neighboring gene PBPb domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

  • Curated pseudogene

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitinyl hydrolase 1
NP_001379688.1
  • Confirmed by transcript evidence
NP_001379689.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5626815..5630951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393078.1 → NP_001379688.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYU7
    Conserved Domains (1) summary
    pfam00443
    Location:80 → 392
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_001393079.1 → NP_001379689.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86MP8
    Conserved Domains (1) summary
    pfam00443
    Location:33 → 345
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
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