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damt-1 DNA N6-methyl methyltransferase [ Caenorhabditis elegans ]

Gene ID: 173970, updated on 4-Jan-2025

Summary

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Official Symbol
damt-1
Official Full Name
DNA N6-methyl methyltransferase
Primary source
WormBase:WBGene00015939
Locus tag
CELE_C18A3.1
See related
AllianceGenome:WB:WBGene00015939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in epigenetic regulation of gene expression. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See damt-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (5720148..5721791)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative rRNA-processing protein EBP2 homolog Neighboring gene ncRNA Neighboring gene Zinc/iron permease Neighboring gene Ras-related protein Rab-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences. Woodcock CB, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32453412, Free PMC Article
  2. DNA Methylation on N6-Adenine in C. elegans. Greer EL, et al. Cell, 2015 May 7. PMID 25936839, Free PMC Article
  3. N(6)-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress. Wan QL, et al. Sci Adv, 2021 Jan. PMID 33523838, Free PMC Article
  4. DNA methylation 6 mA and histone methylation involved in multi-/trans-generational reproductive effects in Caenorhabditis elegans induced by Atrazine. Yin J, et al. Ecotoxicol Environ Saf, 2023 Jan 1. PMID 36508798
  5. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity, acting on a nucleic acid IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables site-specific DNA-methyltransferase (adenine-specific) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA N6-methyl methyltransferase
NP_495127.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5720148..5721791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062726.3 → NP_495127.1  DNA N6-methyl methyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495127.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09956
    Conserved Domains (1) summary
    cl01947
    Location:185 → 349
    MT-A70; MT-A70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09956.1

Gene LinkOut

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