ifb-1 Intermediate filament protein ifb-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ifb-1
Official Full Name: Intermediate filament protein ifb-1
Primary source: WormBase:WBGene00002053
Locus tag: CELE_F10C1.2
See related: AllianceGenome:WB:WBGene00002053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Located in apical plasma membrane. Is expressed in several structures, including egg-laying apparatus; excretory system; hypodermis; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ifb-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (5765618..5772084)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic and imaging analyses suggest that IFB-1/IFA-4 and IFB-1/IFC-2 polymers form a perilumenal triple IF lattice, sandwiched between actin and helical tubulin. Our findings characterize a novel mechanism of capillary-like lumenogenesis, where a tensile trilayered cytoskeletal endotube transforms concentric into directional growth.
Title: A tensile trilayered cytoskeletal endotube drives capillary-like lumenogenesis.
IFA-1 and IFB-1 form a heteropolymeric intermediate filaments system in the C. elegans tissue.
Title: Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs.
observations indicate that SUMO regulates cytoplasmic intermediate filament assembly by maintaining a cytoplasmic pool of nonpolymerized IFB-1, and that this is necessary for normal IFB-1 function.
Title: SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10C1.2 (e-PCR)
- UniSTS:317468

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Intermediate filament protein ifb-1

NP_001379694.1

Confirmed by transcript evidence

NP_495137.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5765618..5772084

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393083.1 → NP_001379694.1 Intermediate filament protein ifb-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19289, Q19290, Q21063

Conserved Domains (1) summary

pfam00038
Location:81 → 432

Filament; Intermediate filament protein
NM_062736.5 → NP_495137.1 Intermediate filament protein ifb-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495137.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19289

Conserved Domains (2) summary

pfam00038
Location:50 → 401

Filament; Intermediate filament protein

pfam00932
Location:440 → 550

LTD; Lamin Tail Domain