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gldc-1 Glycine cleavage system P protein [ Caenorhabditis elegans ]

Gene ID: 174012, updated on 2-Nov-2024

Summary

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Official Symbol
gldc-1
Official Full Name
Glycine cleavage system P protein
Primary source
WormBase:WBGene00020022
Locus tag
CELE_R12C12.1
See related
AllianceGenome:WB:WBGene00020022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and pyridoxal phosphate binding activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in head; hypodermis; and intestine. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gldc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (6050420..6054307)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RanBD1 domain-containing protein Neighboring gene Zf-AD domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Cordeiro Rodrigues RJ, et al. Genes Dev, 2019 Jul 1. PMID 31147388, Free PMC Article
  2. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine decarboxylation via glycine cleavage system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glycine cleavage complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycine cleavage system P protein
NP_001335514.1
  • Confirmed by transcript evidence
NP_495209.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6050420..6054307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062808.9 → NP_495209.1  Glycine cleavage system P protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495209.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21962
    Conserved Domains (3) summary
    COG1003
    Location:495 → 947
    GcvP2; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]
    PRK05367
    Location:28 → 979
    PRK05367; glycine dehydrogenase; Provisional
    pfam02347
    Location:32 → 462
    GDC-P; Glycine cleavage system P-protein

  2. NM_001348634.3 → NP_001335514.1  Glycine cleavage system P protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LS6
    Conserved Domains (1) summary
    PRK05367
    Location:2 → 915
    PRK05367; glycine dehydrogenase; Provisional
Nucleotide Protein
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