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B0252.3 Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3 [ Caenorhabditis elegans ]

Gene ID: 174130, updated on 9-Dec-2024

Summary

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Official Symbol
B0252.3
Official Full Name
Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3
Primary source
WormBase:WBGene00015088
Locus tag
CELE_B0252.3
See related
AllianceGenome:WB:WBGene00015088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to several human genes including SLC22A11 (solute carrier family 22 member 11); SLC22A14 (solute carrier family 22 member 14); and SLC22A24 (solute carrier family 22 member 24). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See B0252.3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (6902846..6907757, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene putative 26S proteasome non-ATPase regulatory subunit 9 Neighboring gene Sphingomyelin phosphodiesterase 1 Neighboring gene Peptidyl-prolyl cis-trans isomerase 10 Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Major facilitator superfamily (MFS) profile domain-containing protein;Putative transporter B0252.3
NP_001021888.1
  • Partially confirmed by transcript evidence
NP_001021889.1
  • Confirmed by transcript evidence
NP_001367331.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6902846..6907757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381468.2 → NP_001367331.1  Putative transporter B0252.3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl28910
    Location:1 → 267
    MFS; Major Facilitator Superfamily

  2. NM_001026717.6 → NP_001021888.1  Putative transporter B0252.3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021888.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10917, Q7YZF8
    Conserved Domains (1) summary
    cd06174
    Location:87 → 454
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_001026718.5 → NP_001021889.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021889.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JXY5
    Conserved Domains (2) summary
    PRK10077
    Location:186 → 246
    xylE; D-xylose transporter XylE; Provisional
    cd17317
    Location:53 → 434
    MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10917.3

Gene LinkOut

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