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tcer-1 Transcription elongation regulator 1;WW domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174150, updated on 4-Jan-2025

Summary

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Official Symbol
tcer-1
Official Full Name
Transcription elongation regulator 1;WW domain-containing protein
Primary source
WormBase:WBGene00022855
Locus tag
CELE_ZK1127.9
See related
AllianceGenome:WB:WBGene00022855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Located in nuclear periphery. Is expressed in several structures, including germ cell; gonad; hypodermal cell; intestinal cell; and somatic cell. Orthologous to several human genes including TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tcer-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (7045874..7050071, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase-like protein cin-4 Neighboring gene pseudo Neighboring gene putative RNA 3'-terminal phosphate cyclase-like protein Neighboring gene TIGR04255 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. Ghazi A, et al. PLoS Genet, 2009 Sep. PMID 19749979, Free PMC Article
  2. The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. Amrit FRG, et al. Nat Commun, 2019 Jul 17. PMID 31316054, Free PMC Article
  3. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. Amrit FR, et al. PLoS Genet, 2016 Feb. PMID 26862916, Free PMC Article
  4. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Holbert S, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172033, Free PMC Article
  5. The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation. De Vaux V, et al. Aging Cell, 2013 Dec. PMID 23815345

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study data establish key roles for TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, in coordinating immunity, longevity and fertility, and reveal mechanisms that distinguish length of life from functional aspects of aging.
    Title: The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.
  2. two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the expression of multiple genes involved in lipid synthesis and breakdown and promote longevity.
    Title: DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.
  3. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan.
    Title: A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
  4. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.
    Title: PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Transcription elongation regulator 1;WW domain-containing protein
NP_001368025.1
  • Confirmed by transcript evidence
NP_001370832.1
  • Confirmed by transcript evidence
NP_001380059.1
  • Confirmed by transcript evidence
NP_001380060.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7045874..7050071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383878.2 → NP_001370832.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PX7
    Conserved Domains (3) summary
    smart00456
    Location:168 → 195
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:235 → 820
    PRP40; Splicing factor [RNA processing and modification]
    pfam01846
    Location:834 → 891
    FF; FF domain

  2. NM_001381486.2 → NP_001368025.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PX8
    Conserved Domains (3) summary
    smart00456
    Location:159 → 186
    WW; Domain with 2 conserved Trp (W) residues
    COG5104
    Location:226 → 811
    PRP40; Splicing factor [RNA processing and modification]
    pfam01846
    Location:825 → 882
    FF; FF domain

  3. NM_001393111.1 → NP_001380059.1  Transcription elongation regulator 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PX9
    Conserved Domains (2) summary
    smart00441
    Location:549 → 606
    FF; Contains two conserved F residues
    COG5104
    Location:14 → 563
    PRP40; Splicing factor [RNA processing and modification]

  4. NM_001393112.1 → NP_001380060.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86MN9
    Conserved Domains (1) summary
    smart00456
    Location:159 → 186
    WW; Domain with 2 conserved Trp (W) residues
Nucleotide Protein
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