hsp-4 Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: hsp-4
Official Full Name: Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D
Primary source: WormBase:WBGene00002008
Locus tag: CELE_F43E2.8
See related: AllianceGenome:WB:WBGene00002008
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in endoplasmic reticulum unfolded protein response. Located in rough endoplasmic reticulum. Is expressed in PVD; hypodermis; intestine; and reproductive system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See hsp-4 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (7350112..7352518, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress.
Title: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress.
We found no evidence for an HSP-4 response during acute or prolonged exposure to concentrations of ethanol that lead to defined ethanol-induced behaviours
Title: HSP-4 endoplasmic reticulum (ER) stress pathway is not activated in a C. elegans model of ethanol intoxication and withdrawal.
The endoplasmic reticulum-resident HSP-4 prtoein is key nutritional sensors that modulate expression of inducible lipases to maintain whole-body energy homeostasis in C. elegans.
Title: IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F43E2.8 (e-PCR)
- UniSTS:310303

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D

NP_001293470.1

Confirmed by transcript evidence

NP_001370395.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7350112..7352518 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383885.2 → NP_001370395.1 Endoplasmic reticulum chaperone BiP homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O02085, P20163

Conserved Domains (1) summary

PTZ00009
Location:33 → 643

PTZ00009; heat shock 70 kDa protein; Provisional
NM_001306541.3 → NP_001293470.1 Heat shock 70 kDa protein D [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293470.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CL98

Conserved Domains (1) summary

PTZ00009
Location:1 → 310

PTZ00009; heat shock 70 kDa protein; Provisional