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alfa-1 ALS/FTD Associated gene homolog [ Caenorhabditis elegans ]

Gene ID: 174236, updated on 9-Dec-2024

Summary

Official Symbol
alfa-1
Official Full Name
ALS/FTD Associated gene homolog
Primary source
WormBase:WBGene00017547
Locus tag
CELE_F18A1.6
See related
AllianceGenome:WB:WBGene00017547
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in autophagy and endocytosis. Predicted to be active in autophagosome and endosome. Is expressed in several structures, including intestine. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis 1. Orthologous to human C9orf72 (C9orf72-SMCR8 complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See alfa-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7658325..7662288, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene putative replication factor A 73 kDa subunit

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ALS/FTD Associated gene homolog
NP_495603.1
  • Product from WormBase gene class alfa;
    Confirmed by transcript evidence
NP_495604.1
  • Product from WormBase gene class alfa;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7658325..7662288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063203.6NP_495604.1  ALS/FTD Associated gene homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYA3
    Conserved Domains (1) summary
    pfam15019
    Location:349592
    C9orf72-like; C9orf72-like protein family
  2. NM_063202.9NP_495603.1  ALS/FTD Associated gene homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495603.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QK5
    Conserved Domains (1) summary
    pfam15019
    Location:352595
    C9orf72-like; C9orf72-like protein family