mthf-1 putative methylenetetrahydrofolate reductase (NADPH) [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mthf-1
Official Full Name: putative methylenetetrahydrofolate reductase (NADPH)
Primary source: WormBase:WBGene00015512
Locus tag: CELE_C06A8.1
See related: AllianceGenome:WB:WBGene00015512
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Is expressed in several structures, including intestine; muscle cell; nervous system; pharynx; and tail. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mthf-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (7773908..7777823, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C06A8.1 (e-PCR)
- UniSTS:308486

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	ISS Inferred from Sequence or Structural Similarity more info
enables methylenetetrahydrofolate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: putative methylenetetrahydrofolate reductase (NADPH)

NP_741027.1

Confirmed by transcript evidence

NP_741028.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7773908..7777823 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171024.7 → NP_741027.1 putative methylenetetrahydrofolate reductase (NADPH) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741027.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G8JXY2, Q17693

Conserved Domains (1) summary

cl00246
Location:73 → 644

MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
NM_171025.9 → NP_741028.1 putative methylenetetrahydrofolate reductase (NADPH) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741028.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17693

Conserved Domains (1) summary

cl00246
Location:52 → 623

MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...