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rev-1 DNA repair protein REV1 [ Caenorhabditis elegans ]

Gene ID: 174275, updated on 2-Nov-2024

Summary

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Official Symbol
rev-1
Official Full Name
DNA repair protein REV1
Primary source
WormBase:WBGene00014066
Locus tag
CELE_ZK675.2
See related
AllianceGenome:WB:WBGene00014066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-directed DNA polymerase activity and deoxycytidyl transferase activity. Predicted to be involved in error-free translesion synthesis and error-prone translesion synthesis. Predicted to be located in nucleus. Is expressed in intestine; neurons; and vm1. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rev-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (7900622..7904667)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein patched homolog 1;SSD domain-containing protein Neighboring gene ncRNA Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene F-BAR domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combined loss of three DNA damage response pathways renders C. elegans intolerant to light. van Bostelen I, et al. DNA Repair (Amst), 2017 Jun. PMID 28472716
  2. Nucleotide Excision Repair, XPA-1, and the Translesion Synthesis Complex, POLZ-1 and REV-1, Are Critical for Interstrand Cross-Link Repair in Caenorhabditis elegans Germ Cells. Oh S, et al. Biochemistry, 2020 Sep 29. PMID 32945661, Free PMC Article
  3. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
  4. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. Holway AH, et al. J Cell Biol, 2006 Mar 27. PMID 16549501, Free PMC Article
  5. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein REV1
NP_495663.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7900622..7904667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063262.4 → NP_495663.1  DNA repair protein REV1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09615
    Conserved Domains (3) summary
    cd01701
    Location:381 → 802
    PolY_Rev1; DNA polymerase Rev1
    COG0389
    Location:440 → 809
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
    pfam00533
    Location:251 → 326
    BRCT; BRCA1 C Terminus (BRCT) domain
Nucleotide Protein
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