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K02C4.3 USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

Gene ID: 174300, updated on 2-Nov-2024

Summary

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Official Symbol
K02C4.3
Official Full Name
USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1
Primary source
WormBase:WBGene00010502
Locus tag
CELE_K02C4.3
See related
AllianceGenome:WB:WBGene00010502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP25 (ubiquitin specific peptidase 25) and USP28 (ubiquitin specific peptidase 28). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See K02C4.3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (8080783..8086853, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene FCH domain-containing protein Neighboring gene Lim and transglutaminase domain protein ltd-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
USP domain-containing protein;putative ubiquitin carboxyl-terminal hydrolase K02C4.3;ubiquitinyl hydrolase 1
NP_001309441.1
  • Confirmed by transcript evidence
NP_001309569.1
  • Confirmed by transcript evidence
NP_001309570.1
  • Confirmed by transcript evidence
NP_001309571.1
  • Confirmed by transcript evidence
NP_001309572.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8080783..8086853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322743.2 → NP_001309570.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09931
    UniProtKB/TrEMBL
    A0A131MAU8
    Conserved Domains (2) summary
    cd02665
    Location:169 → 745
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:169 → 299
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  2. NM_001322741.2 → NP_001309569.1  USP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09931
    UniProtKB/TrEMBL
    A0A131MAZ4
    Conserved Domains (2) summary
    cd02665
    Location:169 → 745
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:169 → 299
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  3. NM_001322744.2 → NP_001309441.1  putative ubiquitin carboxyl-terminal hydrolase K02C4.3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09931
    Conserved Domains (3) summary
    cd02665
    Location:169 → 745
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:169 → 299
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:168 → 744
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. NM_001322742.3 → NP_001309571.1  USP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09931
    UniProtKB/TrEMBL
    A0A131MBF0
    Conserved Domains (2) summary
    cd02665
    Location:169 → 745
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:169 → 299
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  5. NM_001322745.3 → NP_001309572.1  putative ubiquitin carboxyl-terminal hydrolase K02C4.3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCC3
Nucleotide Protein
Heading Accession and Version

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