ran-3 Regulator of chromosome condensation [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ran-3
Official Full Name: Regulator of chromosome condensation
Primary source: WormBase:WBGene00004304
Locus tag: CELE_C26D10.1
See related: AllianceGenome:WB:WBGene00004304
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in embryo development and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ran-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (8322612..8325052, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C26D10.1 (e-PCR)
- UniSTS:321239

C26D10.3 (e-PCR)
- UniSTS:321240

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Regulator of chromosome condensation

NP_495753.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8322612..8325052 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063352.7 → NP_495753.1 Regulator of chromosome condensation [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18211

Conserved Domains (3) summary

COG5184
Location:163 → 569

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

pfam00415
Location:510 → 565

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:302 → 331

RCC1_2; Regulator of chromosome condensation (RCC1) repeat