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eff-1 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174334, updated on 4-Jan-2025

Summary

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Official Symbol
eff-1
Official Full Name
Protein kinase domain-containing protein
Primary source
WormBase:WBGene00001159
Locus tag
CELE_C26D10.5
See related
AllianceGenome:WB:WBGene00001159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables fusogenic activity and identical protein binding activity. Involved in several processes, including egg-laying behavior; male anatomical structure morphogenesis; and nematode pharyngeal muscle development. Located in cell-cell contact zone; cytoplasm; and plasma membrane. Is expressed in several structures, including P3.pa; P3.pp; hypodermis; tail spike; and vulval cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See eff-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (8346684..8350563)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene G protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fusogenic activity of EFF-1 is regulated via dynamic localization in fusing somatic cells of C. elegans. del Campo JJ, et al. Curr Biol, 2005 Mar 8. PMID 15753035
  2. Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Gattegno T, et al. Mol Biol Cell, 2007 Apr. PMID 17229888, Free PMC Article
  3. EFF-1 is sufficient to initiate and execute tissue-specific cell fusion in C. elegans. Shemer G, et al. Curr Biol, 2004 Sep 7. PMID 15341747
  4. The story of cell fusion: big lessons from little worms. Shemer G, et al. Bioessays, 2003 Jul. PMID 12815722
  5. LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion. Shemer G, et al. Genes Dev, 2002 Dec 15. PMID 12502736, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans.
    Title: A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans.
  2. Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans.
    Title: Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans.
  3. we show that the small GTPase RAB-5 is a key cell-intrinsic regulator of the fusogen EFF-1 and can in turn regulate axonal fusion
    Title: Disruption of RAB-5 Increases EFF-1 Fusogen Availability at the Cell Surface and Promotes the Regenerative Axonal Fusion Capacity of the Neuron.
  4. EFF-1 localizes to phagocyte pseudopod tips and acts exoplasmically to drive phagosome sealing.
    Title: EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans.
  5. EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
    Title: Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells.
  6. let-7 miRNA inhibits functional restoration via EFF-1-mediated axonal self-fusion by reducing ced-7 expression.
    Title: let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury.
  7. Endocytosis regulates membrane localization and function of the fusogen EFF-1
    Title: Endocytosis regulates membrane localization and function of the fusogen EFF-1.
  8. EFF-1 and AFF-1 fusion proteins emerge as new players in neuronal arborization and maintenance of arbor connectivity following injury in Caenorhabditis elegans Our results demonstrate that there is a genetically determined multi-step pathway to repair broken dendrites in which EFF-1 and AFF-1 act on different steps of the pathway.
    Title: Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion in Caenorhabditis elegans.
  9. EFF-1 enhanced the F-actin bundling activity of VAB-10A in vitro, and actin dynamics in the cortex were reduced in eff-1 or vab-10a mutants.
    Title: Spectraplakin Induces Positive Feedback between Fusogens and the Actin Cytoskeleton to Promote Cell-Cell Fusion.
  10. RAB-5- and DYNAMIN-1-mediated endocytosis of EFF-1 fusogen controls cell-cell fusion.
    Title: RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fusogenic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharyngeal muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in syncytium formation by plasma membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in syncytium formation by plasma membrane fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein kinase domain-containing protein
NP_001021987.1
  • Confirmed by transcript evidence
NP_001021988.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8346684..8350563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026817.5 → NP_001021988.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBM0
    Conserved Domains (1) summary
    pfam14884
    Location:16 → 583
    EFF-AFF; Type I membrane glycoproteins cell-cell fusogen

  2. NM_001026816.7 → NP_001021987.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECA1
    Conserved Domains (1) summary
    pfam14884
    Location:68 → 547
    EFF-AFF; Type I membrane glycoproteins cell-cell fusogen

RNA

  1. NR_136365.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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