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prx-5 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174392, updated on 4-Jan-2025

Summary

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Official Symbol
prx-5
Official Full Name
TPR_REGION domain-containing protein
Primary source
WormBase:WBGene00004194
Locus tag
CELE_C34C6.6
See related
AllianceGenome:WB:WBGene00004194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peroxisome targeting sequence binding activity. Involved in nematode larval development and protein import into peroxisome matrix. Predicted to be active in cytosol and peroxisomal membrane. Is expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to several human genes including PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See prx-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (8704824..8706760)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Sphingosine kinase 1 Neighboring gene Homeobox protein ceh-7 Neighboring gene Uncharacterized protein Neighboring gene Serpentine receptor class gamma-15 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Predicting the function and subcellular location of Caenorhabditis elegans proteins similar to Saccharomyces cerevisiae beta-oxidation enzymes. Gurvitz A, et al. Yeast, 2000 Sep 30. PMID 11025529, Free PMC Article
  2. The tetratricopeptide repeat domains of human, tobacco, and nematode PEX5 proteins are functionally interchangeable with the analogous native domain for peroxisomal import of PTS1-terminated proteins in yeast. Gurvitz A, et al. Mol Genet Genomics, 2001 Apr. PMID 11361338
  3. HLH-30-dependent rewiring of metabolism during starvation in C. elegans. Dall KB, et al. Aging Cell, 2021 Apr. PMID 33724708, Free PMC Article
  4. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article
  5. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxisome matrix targeting signal-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxisome targeting sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TPR_REGION domain-containing protein
NP_001022019.1
  • Confirmed by transcript evidence
NP_001022020.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8704824..8706760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026848.6 → NP_001022019.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022019.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18426
    Conserved Domains (3) summary
    COG0457
    Location:181 → 455
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG5010
    Location:355 → 462
    TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
    sd00006
    Location:360 → 388
    TPR; TPR repeat [structural motif]

  2. NM_001026849.4 → NP_001022020.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JM90
    Conserved Domains (3) summary
    COG0457
    Location:179 → 453
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG5010
    Location:353 → 460
    TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
    sd00006
    Location:358 → 386
    TPR; TPR repeat [structural motif]
Nucleotide Protein
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