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T24B8.7 UBA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174440, updated on 2-Nov-2024

Summary

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Official Symbol
T24B8.7
Official Full Name
UBA domain-containing protein
Primary source
WormBase:WBGene00011980
Locus tag
CELE_T24B8.7
See related
AllianceGenome:WB:WBGene00011980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Orthologous to several human genes including USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T24B8.7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
29
Sequence:
Chromosome: II; NC_003280.10 (9041510..9053664, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Charged multivesicular body protein 7 Neighboring gene 60S ribosomal protein L32;Large ribosomal subunit protein eL32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBA domain-containing protein
NP_001293493.1
  • Confirmed by transcript evidence
NP_001293495.1
  • Confirmed by transcript evidence
NP_001368176.1
  • Partially confirmed by transcript evidence
NP_001368177.1
  • Confirmed by transcript evidence
NP_001368178.1
  • Confirmed by transcript evidence
NP_001368179.1
  • Partially confirmed by transcript evidence
NP_495931.4
  • Partially confirmed by transcript evidence
NP_495932.4
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9041510..9053664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063531.7 → NP_495932.4  UBA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495932.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGM9
    Conserved Domains (3) summary
    smart00165
    Location:133 → 168
    UBA; Ubiquitin associated domain
    cd02659
    Location:1819 → 2234
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1819 → 2229
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_063530.6 → NP_495931.4  UBA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495931.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG81
    Conserved Domains (3) summary
    smart00165
    Location:133 → 168
    UBA; Ubiquitin associated domain
    cd02659
    Location:1819 → 2234
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1819 → 2229
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. NM_001306566.3 → NP_001293495.1  UBA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NVC2
    Conserved Domains (3) summary
    smart00165
    Location:78 → 113
    UBA; Ubiquitin associated domain
    cd02659
    Location:1764 → 2179
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1764 → 2174
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. NM_001306564.3 → NP_001293493.1  UBA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293493.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NTH7
    Conserved Domains (3) summary
    smart00165
    Location:78 → 113
    UBA; Ubiquitin associated domain
    cd02659
    Location:1764 → 2179
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1764 → 2174
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. NM_001381549.1 → NP_001368177.1  UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NTM2
    Conserved Domains (1) summary
    smart00165
    Location:78 → 113
    UBA; Ubiquitin associated domain

  6. NM_001381547.1 → NP_001368179.1  UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NV23
    Conserved Domains (1) summary
    smart00165
    Location:133 → 168
    UBA; Ubiquitin associated domain

  7. NM_001381548.1 → NP_001368176.1  UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NVC1
    Conserved Domains (1) summary
    smart00165
    Location:133 → 168
    UBA; Ubiquitin associated domain

  8. NM_001381550.1 → NP_001368178.1  UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NSH8
    Conserved Domains (1) summary
    smart00165
    Location:78 → 113
    UBA; Ubiquitin associated domain
Nucleotide Protein
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