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rhy-1 Regulator of hypoxia-inducible factor 1 [ Caenorhabditis elegans ]

Gene ID: 174455, updated on 4-Jan-2025

Summary

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Official Symbol
rhy-1
Official Full Name
Regulator of hypoxia-inducible factor 1
Primary source
WormBase:WBGene00012324
Locus tag
CELE_W07A12.7
See related
AllianceGenome:WB:WBGene00012324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Involved in negative regulation of cellular response to hypoxia and response to hypoxia. Located in perinuclear region of cytoplasm. Is expressed in several structures, including body wall musculature; intestine; neurons; socket cell; and vulva. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rhy-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (9161379..9163448)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene Acyltransferase 3 domain-containing protein Neighboring gene DapB_N domain-containing protein Neighboring gene G-patch domain-containing protein Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans. Horsman JW, et al. Genetics, 2019 Oct. PMID 31371406, Free PMC Article
  2. Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection. Burton NO, et al. Nat Commun, 2020 Apr 8. PMID 32269224, Free PMC Article
  3. Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Warnhoff K, et al. Elife, 2024 Feb 13. PMID 38349720, Free PMC Article
  4. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. Bellier A, et al. PLoS Pathog, 2009 Dec. PMID 20011506, Free PMC Article
  5. Co-opted genes of algal origin protect C. elegans against cyanogenic toxins. Wang B, et al. Curr Biol, 2022 Nov 21. PMID 36223775, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
    Title: Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
  2. The rhy-1 gene encodes a predicated O-acyltransferase enzyme that has previously been shown to negatively regulate HIF-1 activity. Our data indicate that RHY-1 has novel, hif-1 independent, function that promotes survival in H2S.
    Title: A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans.
  3. The Caenorhabditis elegans rhy-1 gene inhibits hif-1 activity in a negative feedback loop that does not include vhl-1.
    Title: The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Regulator of hypoxia-inducible factor 1
NP_495954.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9161379..9163448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063553.5 → NP_495954.1  Regulator of hypoxia-inducible factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495954.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XVW1
    Conserved Domains (2) summary
    COG1835
    Location:89 → 489
    OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]
    pfam01757
    Location:95 → 479
    Acyl_transf_3; Acyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XVW1.1

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